<em>In-vitro</em> wound healing potential of <em>Ziziphus oenoplia</em> (L.) Miller

Non-healing wounds are a global health problem. Substances that enhance cell proliferation, angiogenesis, and prevention of bacterial infections accelerate the wound healing process. In this study, potential Ziziphus oenoplia, is investigated for its ability in antibacterial potential. The proliferation enhancement (mean percent closure) angiogenic response vascular index) hexanes, dichloromethane, ethyl acetate, methanol extracts leaf bark Z. oenoplia were evaluated by scratch assay (SWA) using Madin-Darby Canine Kidney (MDCK) cells chick chorioallantoic membrane (CAM) assay, respectively. activity these was against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa disc diffusion method. Enhanced shown acetate hexanes extract bark. An enhanced leaves Dichloromethane both showed considerable P. which less susceptible to common antibiotics. SWA-directed fractionation has resulted isolation identification an active fraction showing mean closure 86.4% (positive control 90.2%) index 34.5 48.6). This contained lupeol, α-amyrin, β-amyrin, hexacosanol, octacosanol. present study provides supportive evidence oenoplia.